![]() Emerging evidence showed that overconsumption of fat or fructose resulted in energy metabolic disruption, impaired mitochondrial dysfunction and autophagy dysregulation, leading to liver damage ( Chen et al., 2019). The ingestion of high-calorie food is strongly associated with fatty liver disease. There are multiple risk factors that related to NAFLD development. It is reported that over 75% of individuals having NAFLD and it becomes the most prevalent liver disease in the world ( Younossi et al., 2011). NAFLD is a spectrum of liver disease that ranges from simple steatosis, non-alcoholic steatohepatitis to fibrosis, and cirrhosis, eventually leading to liver cancer. Importantly, IH exposure altered bile acids composition and shifted the hepatic bile acids towards FXR agonism, which was involved in the protection of IH against HFHFD.Ĭonclusion: These results support that the IH pattern in our model prevents liver injury from HFHFD in experimental NAFLD. However, HFHFD-induced lipid accumulation, lipid peroxidation, neutrophil infiltration, and apoptotic process were significantly attenuated by IH exposure. ![]() Results: IH causes no overt liver injury in mice fed an ND. Indices of liver injury and metabolism were measured. Material and Method: Mice were exposed to IH (2 min cycle, FiO 2 8% for 20 s, FiO 2 20.9% for 100 s 12 h/day) or intermittent air (FiO 2 20.9%) for 15 weeks, with normal diet (ND) or high-fat and high-fructose diet (HFHFD). The current study, therefore, tests the impact of IH on the liver of high-fat and high-fructose diet (HFHFD) fed mice. However, the role of IH in liver injury prevention has been revealed by many other studies based on the different IH paradigms. Intermittent hypoxia (IH), known as the basis of obstructive sleep apnea (OSA), normally is correlated with impaired liver function. The western diet containing high fat and fructose is the risk factor for NAFLD development. 3Department of Pediatric Hematology Disease, Wenzhou, Chinaīackground: The high prevalence of non-alcoholic fatty liver disease (NAFLD) in the world raises an important concern for human health.2The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China.1Department of Pediatric Infectious Disease, Wenzhou, China.Our expert service engineers and chemists can install and custom-configure the system to be compliant with the methods you plan to run.Liya Chen 1,2, Yao Wang 3,2, Weikun Zheng 1,2, Hu Zhang 1,2, Yan Sun 1,2, Yiping Chen 1,2 and Qi Liu 1,2* A full calibration and data verification is performed ensuring our refurbished laboratory instruments are in excellent working condition. Routine maintenance is also addressed and filters, liners, tubing, etc. The instruments undergo in-depth preventative maintenance procedures that include extensive cleaning, detector maintenance, line and pump flushing. How GenTech Refurbishes Used Lab InstrumentsĮvery refurbished instrument we sell undergoes a complete electronics inspection and performance evaluation. Financing Options: Purchase, Leasing and Rental.Service, Repair, and a Large Inventory of Parts.Delivery and Installation with Familiarization Training.Lifetime Phone Support & Remote Troubleshooting.Warranty Coverage with 48 Hour Response Time.Our commitment extends beyond the sale with our warranty and continued service options. Our knowledgeable sales and service team are committed to help you get the right instrument into your lab. GenTech Scientific’s 60,000 square foot facility stocks an extensive multimillion-dollar inventory. Original Quality at Refurbished Prices! Our refurbished analytical instruments have been expertly restored to meet rigid industry standards.
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